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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Erik Alexandersson
Welcome to BMC Systems Biology published by BioMed Central
BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in systems-level analysis of biological events, whether experimental or theoretical, at the level of molecules, cells or organisms. The journal especially welcomes quantitative analyses and those that integrate different levels of information to understand how biological systems function or can be perturbed, as well as articles involving the modeling or engineering of biological systems, and synthetic biology.
BMC Systems Biology (ISSN 1752-0509) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Zoological Record, Thomson Reuters (ISI) and Google Scholar.
Featured articles
BMC Systems Biology 2008, 2 :83
A study of gap gene circuits in Drosophila shows that gene network models can be strengthened by analyzing the quality of parameter estimates in order to distinguish reliable interactions from those which are ambiguous.
BMC Systems Biology 2008, 2 :81
The accuracy of predictions of protein interactions may be improved by employing a cross-species strategy, comparing patterns of co-expressed genes from a number of species using popular co-expression distance measures.
BMC Systems Biology 2008, 2 :50
Complex biological systems are often studied by single gene knockouts, however an in silico yeast model finds that single-perturbation analyzes frequently fail to reveal all the genes involved in a system or their full functions.
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Research article
Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: a dynamic spatial model Mariana Benitez, Carlos Espinosa-Soto, Pablo Padilla-Longoria, Elena R Alvarez-Buylla BMC Systems Biology 2008, 2 :98 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Stochastic analysis of the GAL genetic switch in Saccharomyces cerevisiae: Modeling and experiments reveal hierarchy in glucose repression Vinay Prasad, K V Venkatesh BMC Systems Biology 2008, 2 :97 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Natural selection governs local, but not global, evolutionary gene coexpression networks in Caenorhabditis elegans I. King Jordan, Lee S. Katz, Dee R. Denver, J. Todd Streelman BMC Systems Biology 2008, 2 :96 (13 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome Angela P Presson, Eric M Sobel, Jeanette C Papp, Charlyn J Suarez, Toni Whistler, Mangalathu S Rajeevan, Suzanne D Vernon, Steve Horvath BMC Systems Biology 2008, 2 :95 (6 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Genetic noise control via protein oligomerization Cheol-Min Ghim, Eivind Almaas BMC Systems Biology 2008, 2 :94 (3 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
An in silico method for detecting overlapping functional modules from composite biological networks Ioannis A Maraziotis, Konstantina Dimitrakopoulou, Anastasios Bezerianos BMC Systems Biology 2008, 2 :93 (1 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Dynamics of receptor and protein transducer homodimerisation Julio Vera, Thomas Millat, Walter Kolch, Olaf Wolkenhauer BMC Systems Biology 2008, 2 :92 (31 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
ALC: automated reduction of rule-based models Markus Koschorreck, Ernst Dieter Gilles BMC Systems Biology 2008, 2 :91 (31 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
From protein interactions to functional annotation: graph alignment in Herpes Michal Kolar, Michael Lassig, Johannes Berg BMC Systems Biology 2008, 2 :90 (28 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Simulating in vitro transcriptional response of zinc homeostasis system in Escherichia coli Jiangjun Cui, Jaap A Kaandorp, Catherine M Lloyd BMC Systems Biology 2008, 2 :89 (24 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Case Report
Multiple variations of the urogenital vascular system in a single cadaver: a case report
Raghu Jetti, Praful S Jevoor, Venkat V Ramana, Bhagath P Kumar, Ravishankar Mv, Virupaxi Rd Cases Journal 2008, 1 :344 (22 [Abstract ] [Provisional PDF ]
Software article
Fast Gene Ontology based clustering for microarray experiments Kristian Ovaska, Marko Laakso, Sampsa Hautaniemi BioData Mining 2008, 1 :11 (21 [Abstract ] [Provisional PDF ]
Research article
Genome-wide survey of prokaryotic serine proteases: Analysis of distribution and domain architectures of five serine protease families in prokaryotes Lokesh P Tripathi, Ramanathan Sowdhamini BMC Genomics 2008, 9 :549 (19 [Abstract ] [Provisional PDF ]
Methodology article
Identifying differential correlation in gene/pathway combinations Rosemary Braun, Leslie Cope, Giovanni Parmigiani BMC Bioinformatics 2008, 9 :488 (18 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Database
Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork Arnis Druka, Ilze Druka, Arthur G Centeno, Hongqiang Li, Zhaohui Sun, William T.B. Thomas, Nicola Bonar, Brian J Steffenson, Steven E Ullrich, Andris Kleinhofs, Roger P Wise, Timothy J Close, Elena Potokina, Zewei Luo, Carola Wagner, Gunther F Schweizer, David F Marshall, Michael J Kearsey, Robert W Williams, Robbie Waugh BMC Genetics 2008, 9 :73 (18 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology
Boolean network simulations for life scientists Istvan Albert, Juilee Thakar, Song Li, Ranran Zhang, Reka Albert Source Code for Biology and Medicine 2008, 3 :16 (14 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis Christopher Bradburne, Myung-Chul Chung, Qin Zong, Karen Schlauch, Derong Liu, Taissia Popova, Anna Popova, Charles Bailey, Dan Soppet, Serguei Popov BMC Immunology 2008, 9 :67 (13 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Database
Extension of the COG and arCOG databases by amino acid and nucleotide sequences Florian Meereis, Michael Kaufmann BMC Bioinformatics 2008, 9 :479 (13 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
ArrayPlex: distributed, interactive and programmatic access to genome sequence, annotation, ontology, and analytical toolsets Patrick J Killion, Vishwanath R Iyer Genome Biology 2008, 9 :R159 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
A comprehensive functional analysis of tissue specificity of human gene expression Zoltan Dezso, Yuri Nikolsky, Evgeny Sviridov, Weiwei Shi, Tatiana Serebriyskaya, Damir Dosymbekov, Andrej Bugrim, Eugene Rakhmatulin, Richard Brennan, Alexey Guryanov, Kelly Li, Julie Blake, Raymond Samaha, Tatiana Nikolskaya BMC Biology 2008, 6 :49 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Featured articles 
